DRESS Syndrome from Allopurinol Definition: Drug Reaction with Eosinophilia and Systemic Symptoms DRESS is a rare, potentially life threatening drug induced hypersensitivity reaction. It involves the skin, hematologic system, and internal organs DRESS syndrome DRESS Syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) DRESS Syndrome is a severe, cutaneous, adverse reaction to medicine. DRESS stands for Drug Reaction with Eosinophilia and Systemic Symptoms and the condition can be life threatening. DRESS is DRESS Women's Luxury Designer Orange Dresses, Clothing & Accessories Ulla Johnson